Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 21 2 2026 05 24 187 188 Ali Hosseinsabet Cardiology Department, Tehran Heart Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2026 02 24 2026 05 19 I read with interest the published article titled “Reduced left ventricular global longitudinal strain in the coronary slow flow phenomenon: a systematic review and meta-analysis” in the latest issue of the journal Research in Heart Yield and Translational Medicine, authored by Seifi et al.1 The authors conducted a systematic review and meta-analysis of studies reporting left ventricular global strain in patients with the coronary slow flow phenomenon. I identified several shortcomings in this manuscript, primarily related to the study design and data analysis, which undermine its clarity, reliability, and reproducibility. https://jthc.tums.ac.ir/index.php/jthc/article/view/2441 https://jthc.tums.ac.ir/index.php/jthc/article/download/2441/1270