Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 1 3 2006 07 19 141 145 Majid Maleki Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Gilda Estahbanaty Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Niloufar Samiei Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Fereidoon Noohi Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Ahmad Mohebi Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Zahra ojaghi Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Maryam Esmaeilzadeh Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Anita Sadeghpour Shahid Radjaie Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. Ozlem Soran Cardiovascular Institute, University of Pittsburgh, USA. 2015 10 03 Background: The aim of this study was to echocardiographically assess the effects of EECP (Enhanced External Counterpulsation Therapy) therapy on systolic and diastolic cardiac function. Methods: LVEF (left ventricular ejection fraction), ESV (end-systolic volume), EDV (end-diastolic volume), Sm (myocardial systolic wave), Ea (myocardial early diastolic wave), Vp (propagation velocity), E/Ea (peak early diastolic transmitral flow velocity/Ea), E/Vp and diastolic function grade were studied in twenty-five patients before and after 35 hours of EECP. Results: EECP reduced ESV and EDV and increased EF significantly (p=0.018, 0.013, 0.002, respectively) in patients with baseline LVEF≤50%, but not in patients with baseline LVEF>50%. Patients with E/Ea≥14 had a significant reduction in EDV and ESV (p=0.038 and 0.32, respectively) and an increase in LVEF (p=0.007) after EECP, whereas patients with baseline E/Ea<14 had no significant change in these parameters. Similarly, EECP significantly improved ESV, EDV and LVEF (p=0.014, 0.032, 0.027 respectively) in patients with grades II and III of diastolic dysfunction (decreased compliance) at baseline, but not in patients with normal diastolic function or grade I diastolic dysfunction (impaired relaxation). Patients with Ea<7 cm/sec prior to EECP showed significant improvement in EDV, ESV and LVEF after therapy (p=0.024, 0.015, 0.001), while patients with Ea ≥7cm/sec showed no significant change. Similarly, patients with Sm<7cm/sec prior to EECP showed significant improvement in EDV, ESV and LVEF after EECP (p=0.016, 0.017, 0.006), while patients with Sm ≥7cm/sec did not. Conclusion: These results provide new insight into the hemodynamic effectiveness and potential clinical applications of EECP. https://jthc.tums.ac.ir/index.php/jthc/article/view/25 https://jthc.tums.ac.ir/index.php/jthc/article/download/25/23