Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 150 155 EN Leyla Pourgholi Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Hamidreza Goodarzynejad Department of Cardiac Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Shayan Ziaee Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Elmira Zare Department of Cardiac Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Arash Jalali Department of Cardiac Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammadali Boroumand Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2016 05 30 2019 01 14 Background: Studies on the association between the prothrombin G20210A variant and coronary artery disease (CAD) risk are inconclusive. This study aimed to investigate the possible association between the G20210A variant in the prothrombin gene and documented CAD and its severity. Methods: This study enrolled 1460 patients who were consecutively admitted for elective coronary angiography. Via the standard angiographic techniques, coronary angiographies were done and the presence and severity of CAD were determined through the clinical vessel score and the Gensini score. Prothrombin G20210A genotypes were identified using PCR-RFLP. Results:  This cross-sectional study was performed on 953 men and 507 women at a mean age of 58.21±10.33 years. The median and the interquartile range for the Gensini score were not statistically significantly different between the wild (GG) and mutant (AA+GA) genotypes (P=0.440). The association between the G20210A polymorphism and the severity of CAD with respect to the vessel score also showed no significant linear trend of higher numbers of diseased vessels (P= 0.765 for the Mantel–Haenszel test of linear trend) in the AA+GA genotype as compared with the GG genotype. Conclusion: Our data failed to confirm the hypothesis that the G20210A variant mutation may be a significant determinant of CAD risk or its severity. https://jthc.tums.ac.ir/index.php/jthc/article/view/560 https://jthc.tums.ac.ir/index.php/jthc/article/download/560/867

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 1188 1188 Reza Rahmani Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Amirfarhangh Zand Parsa Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Alborz Sherafati Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Roozbeh Kowsari Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Vahid Mohammadi Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Rizan Mohammadi Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 2019 11 27 The Journal of Tehran University Heart Center hereby declares the retraction of the article entitled “A Rare Case of Cardiogenic Shock following Severe Multivessel Coronary Vasospasm”, which was already published in this journal (J Teh Univ Heart Ctr 2019;14:28-32, DOI: https://doi.org/10.18502/jthc.v14i1.653). This article has been retracted at the request of its authors, who stated that notwithstanding the merits of their reported case, the complicated manifestations of the patient require further causal investigation via a more scrutinized approach. https://jthc.tums.ac.ir/index.php/jthc/article/view/1188 https://jthc.tums.ac.ir/index.php/jthc/article/download/1188/879

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 156 164 Erdoğan Sökmen Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey. Mustafa Çelik Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey. Serkan Sivri Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey. Kenan Güçlü Department of Biochemistry, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey. 2019 01 15 2019 06 22 Background: Although serum paraoxonase-1 (PON-1) and arylesterase (ARE) activities are linked to the presence of stable coronary arterial disease, their correlation with SYNTAX Score I (SS1) and SYNTAX Score II (SS2) has not been known well. Our aim was to determine the association between PON-1 and ARE activities, together with the genetic polymorphism of PON-1, and both SS1 and SS2 in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: Consecutive patients with acute STEMI (n=102: 78 male, 24 female; mean age=61.14±12.25 y) admitted to the Emergency Department of Kırşehir Ahi Evran University Hospital between August 2018 and December 2018 were enrolled. PON-1 and ARE activities were determined on hospital admission. The SS1 and SS2 scores were calculated by using the angiographic and clinical data. Subsequently, the relationships between the activities of the enzymes, together with the genetic polymorphism of PON-1, and both SS1 and SS2 were interrogated. Results: The mean SS1 and the mean SS2 were 19.8±9.7 and 32.3±11.5, respectively. The phenotype distributions of PON-1 were Q192Q (n=60), R192Q (n=35), and R192R (n=7). The respective PON-1 (U/L) and ARE (kU/L) activities were 514.85±29.34 and 216.82±36.72 in the low SS1 category; 527.60±56.31 and 203.95±55.97 in the intermediate SS1 category; and, 690.10±11.07 and 238.48±45.65 in the high SS1 category.PON-1 and ARE activities did not correlate with the SS1 categories, and varying SS2 scores. The distribution of the Q192R polymorphism was homogenous among the different SS1 and SS2 scores. The localization of acute STEMI also did not associate with the activities of either enzyme. Conclusion: Admission serum PON-1 and ARE activities, together with the PON-1 Q192R genetic polymorphism, showed association neither with SS1 and SS2 nor with the localization of infarction in our acute STEMI patients. https://jthc.tums.ac.ir/index.php/jthc/article/view/1024 https://jthc.tums.ac.ir/index.php/jthc/article/download/1024/868

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 165 170 EN Mehdi Safarpour Department of Disease Prevention and Control, Health Deputy, Babol University of Medical Sciences, Babol, Iran. Akbar Fotouhi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Seyed Reza Hosseini Department of Community Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Masume Mohamadzade Department of Disease Prevention and Control, Health Deputy, Babol University of Medical Sciences, Babol, Iran. Ali Bijani Children’s Non-Communicable Diseases Research Center, Babol University of Medical Sciences, Babol, Iran. 2018 06 07 2019 06 12 Background: Orthostatic hypotension (OH) in the elderly is an important health challenge that poses a significant burden. We sought to determine the prevalence and correlates of OH in an elderly population-based study. Methods: This study was conducted within the framework of the Amirkola Health and Ageing Project (AHAP) on 1,588 elderly individuals aged ≥60 years. The baseline measurement was performed from April 2011 to July 2012. The relationships between OH (dependent variable) and age, sex, diabetes, hypertension, and cognitive status (independent variables) were investigated by logistic regression. Results: The mean age of the participants was 69.37±7.42 years (men: 69.96±7.68 y, women: 68.66±7.02 y). The prevalence of OH was 10.7%: 8.4% in the male and 13.7% in the female patients. In the final model, hypertension (OR=2.4, 95% CI: 1.6–3.7), diabetes (OR=1.3, 95% CI: 1.0–1.9), age (OR=2.9, 95% CI: 1.7–4.8), and female sex (female [OR=1.6, 95% CI: 1.1–2.3]) were significantly correlated with OH. Conclusion: The prevalence of OH in our elderly subjects increased with age. Additionally, the older participants with diabetes and hypertension had a higher likelihood of having this OH. https://jthc.tums.ac.ir/index.php/jthc/article/view/899 https://jthc.tums.ac.ir/index.php/jthc/article/download/899/869

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 171 176 EN Kahraman Cosansu Department of Cardiology, Education and Research Hospital, Sakarya University, Adapazarı, Turkey. Harun Kilic Department of Cardiology, Education and Research Hospital, Sakarya University, Adapazarı, Turkey. Ayca Turer Cabbar Department of Cardiology, Yeditepe University, Istanbul, Turkey. Erdinc Hatipsoylu Department of Cardiology, Afsin State Hospital, Kahramanmaras, Turkey. Bilgehan Karadag Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Ramazan Akdemir Department of Cardiology, Education and Research Hospital, Sakarya University, Adapazarı, Turkey. 2018 07 24 2019 06 23 Background: The aim of this study was to investigate the ability of a new index, namely the left ventricular internal dimension at end-diastole/mitral valve E-point septal separation (LVIDd/EPSS), to predict the left ventricular (LV) systolic function and to compare its performance with that of the EPSS index and to investigate the correlation between the LVIDd/EPSS and the left ventricular ejection fraction (LVEF). Methods: The current study recruited 142 patients who presented to the Cardiology Clinic of Sakarya University Education and Research Hospital and were followed for heart failure (HF).M-mode measurements of the EPSS and the LVIDd were recorded in the parasternal long-axis view. Results: Totally, 142 HF patients with midrange ejection fraction (HFmrEF) and reduced ejection fraction (HFrEF) were enrolled in the study. There was a significantly correlation both between the EF and the EPSS and between the EF and the LVIDd/EPSS (P<0.001). In both HFmrEF and HFrEF groups, the correlation between the LVIDd/EPSS and the EF was more significant than was the correlation between the EPSS and the EF (P<0.001). The results of the linear regression analysis indicated that the LVIDd/EPSS was an independent predictor of the HFmrEF and the HFrEF (P<0.001). In the patients with EPSS≤12, there was a significant association between the EF and the LVIDd/EPSS (P<0.001) but not between the EF and the EPSS(P>0.05). The receiver operating characteristic curve analysis showed that the LVIDd/EPSS predicted advanced HF with 87% sensitivity and 72% specificity, using a cutoff value of 3.35,and it predicted the HFrEF (EF<40%) with 84% sensitivity and 81% specificity, using a cutoff value of 3.75. Conclusion: The LVIDd/EPSS may allow certain clinicians, especially beginners and emergency department physicians, to assess the LVEF when other methods are not available or questionable­. https://jthc.tums.ac.ir/index.php/jthc/article/view/939 https://jthc.tums.ac.ir/index.php/jthc/article/download/939/870

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 4 2019 10 19 177 182 EN Mohammad Bagher Khosravi Department of Anesthesia, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Mahdi Kahrom Department of Cardiovascular Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mahdi Tahari Division of Cardiac Perfusion, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Kambiz Alizadeh Department of Cardiovascular Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ghasem Soltani Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Ali Ghanad Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2018 02 20 2019 07 23 Background: Ischemic postconditioning is a novel strategy for attaining cardioprotection. Remarkable evidence from various in vitro and in vivo animal and human studies have shown significant opioid-induced cardioprotection against myocardial ischemia/reperfusion (I/R) injury. The purpose of this study was to assess the cardioprotective effect of sufentanil against I/R injury after on-pump coronary artery bypass grafting (CABG). Methods: Between June 2016 and July 2017, 80 consecutive patients with triple-vessel disease undergoing on-pump CABG were enrolled in this prospective randomized study. The patients assigned to the sufentanil group received a single dose of sufentanil (0.2 μg/kg diluted with 50 cc of saline) 5 minutes before the removal of the aorta cross-clamp, with the sufentanil injected via a cardioplegia needle into the aortic root. In the control group, the same volume of normal saline was injected as a placebo. Cardiac enzymes, the inotrope score, and the outcome data were compared between the 2 groups. Results: The mean age of the patients was 60.48±7.50 years (range=41–69 y), and men comprised 65.0% of the study population. The levels of CK-MB and cardiac troponin I were significantly lower in the sufentanil group (P<0.001). The amount of inotrope use (P<0.001), the incidence of atrial fibrillation (P=0.014), electrical shock (P=0.007), and the mechanical ventilation time (P<0.001) decreased in the sufentanil group compared with the control group. However, the use of intra-aortic balloon pumps (P=0.247) and the ICU length of stay (P=0.867) were not significantly different between the 2 groups. Conclusion: The injection of a single dose of sufentanil into the aortic root prior to aorta cross-clamp removal diminished cardiac injury during on-pump CABG in our patients. http"en_US">Department of Psychology and Educational Sciences, Semnan University, Semnan, Iran. Shahrzad Hoveida Alborz Azad University of Sciences and Research, Karaj, Iran. 2015 12 17 2015 12 17 Background: Healthy lifestyle and ineffective coping strategies are deemed significant variables among patients with hypertension. This study attempted to determine the status of these variables following intervention via the mindfulness-based stress-reduction program (MBSRP) in patients with hypertension. Method: This study was a randomized clinical trial. The study sample, consisting of 30 patients referring to the Hypertension Clinic of Imam Hossein Hospital in 2013, was assigned either to the intervention (recipient of the MBSRP and conscious yoga) or to the control group (recipient of yoga training). The intervention group had 8 training sessions over 8 weeks. Lifestyle and coping strategies as well as blood pressure were measured in the intervention group before intervention and then immediately thereafter and at 2 months' follow-up and were compared to those in the control group at the same time points. Result: The mean age of the patients in the intervention (40% women) and control (53% women) groups was 43.66 ± 5.14 and 43.13 ± 5.04 years, respectively. The results showed that the mean scores of lifestyle (p value < 0.05), emotion-focused coping strategies (p value < 0.001), problem-focused coping strategies (p value < 0.001), diastolic blood pressure (p value < 0.001), and systolic blood pressure (p value < 0.001) were significantly different between the intervention and control groups after the intervention. Conclusion: Applying an intervention based on the MBSRP may further improve the lifestyle and coping strategies of patients with hypertension. https://jthc.tums.ac.ir/index.php/jthc/article/view/428 https://jthc.tums.ac.ir/index.php/jthc/article/download/428/378

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 10 3 2015 12 17 149 151 EN Mustafa Karaçelik Department of Pediatric Cardiac Surgery, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Pelin Öztürk Department of Pediatric Cardiac Surgery, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Onur Doyurgan Department of Pediatric Cardiac Surgery, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Uğur Karagöz Department of Pediatric Cardiac Surgery, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Murat Muhtar Yilmazer Department of Pediatric Cardiology, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Timur Meşe Department of Pediatric Cardiology, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. Osman Nejat Sariosmanoğlu Department of Pediatric Cardiac Surgery, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey. 2015 12 17 2015 12 17 Today, congenital heart diseases may be treated without surgery through advances in interventional cardiology. However, complications such as infection and thrombus formation may develop due to foreign materials used during these procedures. Surgical intervention may be required for the removal of the device utilized for the procedure. In this case report, we present the surgical treatment of a residual ventricular septal defect (VSD) that had developed in a 6-year-old patient with an apical muscular VSD closed with the Amplatzer muscular VSD device. The patient was admitted to the emergency room with complaints of abdominal pain and high fever 5 days after discharge without any cardiac symptoms. When she arrived at our clinic, she had a heart rate of 95 bpm, blood pressure of 110/70 mmHg, and temperature of 38.5ºC. Examinations of the other systems were normal, except for a 3/6 pan-systolic murmur at the mesocardiac focus on cardiac auscultation. Echocardiography showed a residual VSD, and the total pulmonary blood flow to the total systemic blood flow ratio (Qp/Qs) of the residual VSD was 1.8. In the operating room, the Amplatzer device was removed easily with a blunt dissection. The VSD was closed with an autologous fresh pericardial patch. Following the pulmonary artery debanding procedure, the postoperative period was uneventful. The condition of the patient at the time of discharge and in the first postoperative month’s follow-up was good. There was no residual VSD or infection.  https://jthc.tums.ac.ir/index.php/jthc/article/view/434 https://jthc.tums.ac.ir/index.php/jthc/article/download/434/384

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 10 3 2015 12 17 152 155 EN Hamid Amoozgar Neonatology and Cardiac Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Maryam Ahmadipoor Neonatology and Cardiac Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Ahmad Ali Amirghofran Cardiac Surgery Department, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 12 17 2015 12 17 Total anomalous pulmonary venous connection (TAPVC) is an anomaly in which the pulmonary veins are directly connected to one of the systemic veins or drain into the right atrium. Management of pulmonary hypertension after the total correction of this congenital cardiac anomaly is very important. Unligation of the vertical vein in the supracardiac type of this anomaly can be a draining pathway for the prevention of postoperative pulmonary hypertension crisis. Late onset transcatheter closure of the unligated vertical vein after a decrease in pulmonary pressure with the Amplatzer vascular plug type 1can prevent residual left-to-right shunting. Here we describe two patients who previously underwent surgical correction of supracardiac TAPVC and their vertical veinwas partially ligated due to severe pulmonary hypertension. Consequently, because of increased left-to-right shunting in the follow-up period, transcatheter occlusion of the vertical vein was done for them and this procedure seemed safe and less invasive compared to the surgical approach.At 2 years'follow-up, there was marked pulmonary artery pressure and clinical improvement. https://jthc.tums.ac.ir/index.php/jthc/article/view/435 https://jthc.tums.ac.ir/index.php/jthc/article/download/435/385

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 10 3 2015 12 17 156 158 EN Rachid El Haouati Cardiovascular Surgery Unit, Mohamed VI Universitary Hospital, Marrakech, Morocco. Yassine Boukaidi Cardiovascular Surgery Unit, Mohamed VI Universitary Hospital, Marrakech, Morocco. Zahira Zouizra Cardiovascular Surgery Unit, Mohamed VI Universitary Hospital, Marrakech, Morocco. Drissi Boumzebra Cardiovascular Surgery Unit, Mohamed VI Universitary Hospital, Marrakech, Morocco. 2015