ESC 2025 Madrid: Practice-Changing Trials and What They Mean for Cardiology and Electrophysiology
																			
				
								
					
				
					
				
				
				
	
								   
	
	
	Abstract
The European Society of Cardiology Congress (ESC) 2025 in Madrid delivered a concentrated set of
clinical trials with immediate relevance to practice across cardiology subspecialties. While the congress
spanned topics from hypertension and coronary disease to cardiomyopathies and device therapy, a subset
of trials is especially salient for electrophysiologists: comparative outcomes of pulsed-field vs
radiofrequency ablation in atrial fibrillation (AF); strategies for anticoagulation after successful AF ablation;
and broader therapeutic advances (oral myosin inhibitors for obstructive hypertrophic cardiomyopathy
[HCM]) that shift paradigms in medical management. Here, I summarize these trial findings, discuss their
electrophysiology implications, and propose priorities for future research and guideline consideration.
2. Garcia-Pavia P, et al. MAPLE-HCM / ODYSSEY- HCM (oral myosin inhibitors) — ESC Congress 2025 presentations. ACC coverage summary. 1 Oct 2025.
3. European Society of Cardiology. Pulsed-field ablation was not superior to radiofrequency ablation in paroxysmal atrial fibrillation — ESC press release. 31 Aug 2025.
4. Joung B, et al. ALONE-AF: Discontinuation of oral anticoagulation after successful AF ablation — ESC Congress 2025. ESC science news / Professional Heart Daily. 31 Aug 2025.
| Files | ||
| Issue | Vol 20 No 2 (2025) | |
| Section | Editorial | |
| DOI | https://doi.org/10.18502/jthc.v20i2.19840 | |
| Keywords | ||
| ESC2025 Key Trial Findings BEAT-PAROX-AF ALONE-AF ODYSSEY-HCM MAPLE-HCM | ||
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|   | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. | 
 
							 
														
								
									
 
 