Bilateral Deep Vein Thrombosis in an Adolescent with Congenital Rubella Syndrome: A Case Report
Abstract
Bilateral deep vein thrombosis (DVT) is a rare condition among adolescents and represents an uncommon pattern of venous thromboembolism. We report a case of bilateral DVT occurring in the setting of severe pulmonary hypertension and right-sided heart failure secondary to congenital heart disease associated with congenital rubella syndrome (CRS). A 19-year-old female patient, with a history of CRS characterized by the classical triad of unilateral cataract, sensorineural deafness, and congenital heart disease, was admitted to our hospital with shortness of breath, swelling in both legs, and abdominal discomfort. Doppler ultrasonography demonstrated partial thrombotic obstruction of the femoral, popliteal, and posterior tibial veins in both lower extremities. A diagnosis of DVT was established on the fourth day of hospitalization. This case highlights the importance of considering bilateral DVT in patients with CRS who present with lower extremity edema, particularly in the presence of cardiovascular complications.
2. Xu T, Huang Y, Liu Z, Bai Y, Ma Z, Cai X, et al. Heart failure is associated with increased risk of long-term venous thromboembolism. Korean Circ J. 2021;51(9):766-80.
3. Brill A. Multiple Facets of Venous Thrombosis. Int J Mol Sci. 2021 Apr 8;22(8):3853.
4. Chan NC, Weitz JI. Recent advances in understanding, diagnosing and treating venous thrombosis. F1000Res. 2020 Oct 6;9:F1000 Faculty Rev-1206.
5. Schneider DJ, Moore JW. Patent ductus arteriosus. Circulation. 2006;114(17):1873-82.
6. Vynnycky E, Knapp JK, Papadopoulos T, Cutts FT, Hachiya M, Miyano S, et al. Estimates of the global burden of Congenital Rubella Syndrome, 1996–2019. Int J Infect Dis. 2023;137:149-56.
7. Toizumi M, Do CGT, Motomura H, Do TN, Fukunaga H, Iijima M, et al. Characteristics of Patent Ductus Arteriosus in Congenital Rubella Syndrome. Sci Rep. 2019;9:1-12.
8. Kaushik A, Verma S, Kumar P. Congenital rubella syndrome: A brief review of public health perspectives. Indian J Public Health. 2018;62(1):52-4.
9. Majiyagbe OO, Akinsete AM, Adeyemo TA, Salako AO, Ekure EN, Okoromah CAN. Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a developing country. PLoS One. 2022;17(7):1-16.
10. Dammeyer J. Congenital rubella syndrome and delayed manifestations. Int J Pediatr Otorhinolaryngol. 2010;74(9):1067-70.
11. O’Dea AF, Mayhall CA. Delayed manifestations of congenital rubella. J Vis Impair Blind. 1988;82(9):379-81.
12. Sever JL, South MA, Shaver KA. Delayed manifestations of congenital rubella. Rev Infect Dis. 1985 Mar-Apr;7 Suppl 1:S164-9.
13. Gupta V, Verma S, Ramakrishnan S, Hote M, Seth S, Bhargava B. Congenital rubella syndrome presenting in adulthood with fatigue. Circulation. 2013;128(23):2542-5.
14. Wienecke LM, Cohen S, Bauersachs J, Mebazaa A, Chousterman BG. Immunity and inflammation: the neglected key players in congenital heart disease? Heart Fail Rev. 2022;27:1957-71.
15. Mawson AR, Croft AM. Rubella virus infection, the congenital rubella syndrome, and the link to autism. J Pediatr. 1975;87(6):875-82.
| Files | ||
| Issue | Vol 21 No 2 (2026) | |
| Section | Case Report(s) | |
| Keywords | ||
| Bilateral Deep Vein Thrombosis Congenital Rubella Syndrome Thromboembolism | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |

