Assessment of Transmural Dispersion of Repolarization in Children with Mitral Valve Prolapse

Transmural dispersion of repolarization on mitral valve prolapses

  • Yazdan Ghandi Mail Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran.
  • Bita Ghahremani Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran.
  • Danial Habibi Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Afsane Pouya Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran.
  • Saiid Sadrnia Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran.
Keywords:
Arrhythmias; cardiac, Child, Mitral valve prolapse

Abstract

Background: Children with mitral valve prolapse (MVP) may be prone to ventricular arrhythmias due to transmural dispersion of repolarization (TDR). This study aimed to assess alterations in ventricular repolarization in children with MVP and to investigate their relationships with the degree of mitral regurgitation.

Methods: Fifty children with MVP and 50 age- and sex-matched healthy children as controls were studied. Twelve-lead electrocardiography and echocardiography were performed in all the subjects. TDR parameters were QT and QTc intervals, QTc dispersion, Tp-e interval, Tp-e interval dispersion, Tp-e/QT, Tp-e/QTc, JTc, JTc dispersion, Tp-e/JT, and Tp-e/JTc.

Results: The mean age of the 50 patients with MVP was 12.45±2.50 years (F/M: 15/35). There were no significant differences in QT and QTc intervals between the 2 groups. QTc dispersion (P=0.001), Tp-e dispersion interval (P=0.002), Tp-e/QTc (P=0.001), JTc dispersion (P=0.023), Tp-e/JT (P=0.004), and Tp-e/JTc (P=0.002) were significantly higher in the patients with MVP than in the healthy controls. Positive correlations were found between Tp-e dispersion interval and Tp-e/QTc and an increase in the degree of mitral regurgitation (P=0.012, r=0.42 and P=0.004, r=0.31, respectively). Additionally, positive correlations were detected between JTc dispersion and Tp-e/JTc and an increase in the degree of mitral regurgitation (P=0.032, r=0.20 and P=0.024, r=0.42, correspondingly).

Conclusion: In this study, TDR was damaged in children with MVP and was positively correlated with an increase in the degree of mitral regurgitation. It appears that children with MVP are prone to life-threatening ventricular arrhythmias.

References

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Published
2020-04-30
How to Cite
1.
Ghandi Y, Ghahremani B, Habibi D, Pouya A, Sadrnia S. Assessment of Transmural Dispersion of Repolarization in Children with Mitral Valve Prolapse. J Tehran Heart Cent. 15(2):64-68.
Section
Original Article(s)