Peripheral Levels of the Brain-Derived Neurotrophic Factor in Coronary Artery Disease: A Systematic Review and Meta-Analysis
Abstract
Background: Among its functions, brain-derived neurotrophic factor (BDNF) regulates endothelial and macrophage activation, possibly playing a role in atherosclerotic plaque pathophysiology. Given contradicting reports, this study sought to investigate whether blood levels of BDNF differed between patients with coronary heart disease (CHD) and controls.
Methods: We explored PubMed, Embase, Web of Science, and Cochrane Library for studies comparing BDNF blood levels in patients with CHD and controls. Random-effect meta-analysis was conducted to calculate the standardized mean differences (SMD) and 95% confidence intervals (CI). The Newcastle-Ottawa scale was used to evaluate the quality of included articles, and statistical analyses were conducted using R version 4.0.4.
Results: The final analysis comprised 12 investigations covering 1422 CHD cases and 929 controls with mean ages of 59.66±13.56 and 53.78±13.61 years, respectively. The initial analyses revealed a tendency toward low levels of BDNF in the CHD group compared with the control group (SMD= -0.41; 95% CI, -1.12 to 0.30; P=0.26). After the removal of outliers, the difference achieved statistical difference (SMD= -0.56; 95% CI, -0.93 to -0.19; P<0.01). Subgroup analysis demonstrated no significant difference between serum and plasma BDNF levels (P=0.54); however, subgroup analyses of studies investigating plasma BDNF showed that patients with CHD had significantly lower BDNF levels.
Conclusion: Serum and plasma BDNF concentrations were considerably lower in patients with CHD than in healthy controls. Further studies of higher quality are required on the potential role of BDNF as a biomarker of CHD pathophysiology and severity.
1. Tousoulis D, Charakida M, Stefanadis C. Endothelial function and inflammation in coronary artery disease. Postgrad Med J 2008;84:368-371.
2. Munnur RK, Nerlekar N, Wong DT. Imaging of coronary athero sclerosis in various susceptible groups. Cardiovasc Diagn Ther 2016:382-395.
3. Pasipoularides A. Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology. Int J Cardiol 2017;230:384-401.
4. Wu Y, Pan N, An Y, Xu M, Tan L, Zhang L. Diagnostic and Prog nostic Biomarkers for Myocardial Infarction. Front Cardiovasc Med 2021;7:617277.
5. Raygan F, Etminan A, Mohammadi H, Akbari H, Nikoueinejad H. Serum Levels of Growth Differentiation Factor-15 as an In flammatory Marker in Patients with Unstable Angina Pectoris. J Tehran Heart Cent 2021;16:15-19.
6. Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 2015;11:1164-1178.
7. Scalzo P, Kümmer A, Bretas TL, Cardoso F, Teixeira AL. Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease. J Neurol 2010;257:540-545.
8. Numakawa T, Odaka H, Adachi N. Actions of Brain-Derived Neu rotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases. Int J Mol Sci 2018;19:3650.
9. Clegg DO, Large TH, Bodary SC, Reichardt LF. Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy. Dev Biol 1989;134:30-37.
10. Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tan don NN, Sun B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000;470:113-117.
11. Donovan MJ, Miranda RC, Kraemer R, McCaffrey TA, Tessa rollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L, et al. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 1995;147:309-324.
12. Barouch R, Appel E, Kazimirsky G, Brodie C. Macrophages ex press neurotrophins and neurotrophin receptors. Regulation of ni tric oxide production by NT-3. J Neuroimmunol 2001;112:72-77.
13. Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neu rotrophic factor in vitro and in inflammatory brain lesions: a neu roprotective role of inflammation? J Exp Med 1999;189:865-870.
14. Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM; Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concen trations and the risk of cardiovascular disease in the community. J Am Heart Assoc 2015 Mar;4:e001544.
15. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neuro trophic factor is an endothelial cell survival factor required for in tramyocardial vessel stabilization. Development 2000;127:4531- 4540.
16. László A, Lénárt L, Illésy L, Fekete A, Nemcsik J. The role of neu rotrophins in psychopathology and cardiovascular diseases: psy chosomatic connections. J Neural Transm (Vienna) 2019;126:265- 278.
17. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, Driscoll I, Ferrucci L, Martin B, Mattson MP. Circu lating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One 2010;5:e10099.
18. Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM; Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concen trations and the risk of cardiovascular disease in the community. J Am Heart Assoc. 2015 Mar 11;4(3):e001544.
19. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Pre ferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-269, W64.
20. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta analyses. Eur J Epidemiol 2010;25:603-605.
21. Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quar tile range. Stat Methods Med Res 2018;27:1785-1805.
22. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or in terquartile range. BMC Med Res Methodol 2014;14:135.
23. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Chichester (UK): John Wiley & Sons; 2019. 24. Begg CB, Mazumdar M. Operating characteristics of a rank cor relation test for publication bias. Biometrics 1994;50:1088-1101.
25. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta analysis detected by a simple, graphical test. BMJ 1997;315:629- 634.
26. Amadio P, Cosentino N, Eligini S, Barbieri S, Tedesco CC, San drini L, Zarà M, Fabiocchi F, Niccoli G, Magnani G, Fracassi F, Crea F, Veglia F, Marenzi G, Barbieri SS. Potential Relation be tween Plasma BDNF Levels and Human Coronary Plaque Mor phology. Diagnostics (Basel) 2021;11:1010.
27. Aslan G, Polat V, Bozcali E, Şahin MH, Çetin N, Ural D. Evalua tion of serum platelet-derived growth factor receptor-ß and brain derived neurotrophic factor levels in microvascular angina. Anatol J Cardiol 2020;24:397-404.
28. Bai HL, Lu ZF, Zhao JJ, Ma X, Li XH, Xu H, Wu SG, Kang CM, Lu JB, Xu YJ, Xiao L, Wu Q, Ye S, Wang Q, Zheng L, Hu YW. Microarray profiling analysis and validation of novel long non coding RNAs and mRNAs as potential biomarkers and their func tions in atherosclerosis. Physiol Genomics 2019;51:644-656.
29. Ejiri J, Inoue N, Kobayashi S, Shiraki R, Otsui K, Honjo T, Taka hashi M, Ohashi Y, Ichikawa S, Terashima M, Mori T, Awano K, Shinke T, Shite J, Hirata K, Yokozaki H, Kawashima S, Yokoyama M. Possible role of brain-derived neurotrophic factor in the patho genesis of coronary artery disease. Circulation 2005;112:2114- 2120.
30. Esmaeili F, Mansouri E, Emami MA, Montazerghaem H, Hosseini Teshnizi S, Kheirandish M, Koochakkhani S, Eftekhar E. Asso ciation of Serum Level and DNA Methylation Status of Brain Derived Neurotrophic Factor with the Severity of Coronary Artery Disease. Indian J Clin Biochem 2022;37:159-168.
31. Han W, Zhang C, Wang H, Yang M, Guo Y, Li G, Zhang H, Wang C, Chen D, Geng C, Jiang P. Alterations of irisin, adropin, preptin and BDNF concentrations in coronary heart disease patients co morbid with depression. Ann Transl Med 2019;7:298.
32. Jin H, Chen Y, Wang B, Zhu Y, Chen L, Han X, Ma G, Liu N. As sociation between brain-derived neurotrophic factor and von Will ebrand factor levels in patients with stable coronary artery disease. BMC Cardiovasc Disord 2018;18:23.
33. Monisha KG, Prabu P, Chokkalingam M, Murugesan R, Milen kovic D, Ahmed SSSJ. Clinical utility of brain-derived neuro trophic factor as a biomarker with left ventricular echocardio graphic indices for potential diagnosis of coronary artery disease. Sci Rep 2020;10:16359.
34. Sustar A, Perkovic MN, Erjavec GN, Strac DS, Pivac N. Associa tion between reduced brain-derived neurotrophic factor concentra tion & coronary heart disease. Indian J Med Res 2019;150:43-49.
35. Xia F, Zeng Q, Chen J. Circulating brain-derived neurotrophic factor dysregulation and its linkage with lipid level, stenosis de gree, and inflammatory cytokines in coronary heart disease. J Clin Lab Anal 2022;36:e24546.
36. Florent B, Maxime B, Catherine-Alexandra G, Christine G, Na thalie TT, Eric T, Anil N, Martin J, Jonathan T, Mathieu G, Louis B. Differences in cognitive function, cardiorespiratory fitness and BDNF concentration in physically active CHD patients vs healthy controls. Brain Res 2022;1793:148019.
37. Wu Y, Wang L, Zhan Y, Zhang Z, Chen D, Xiang Y, Xie C. The ex pression of SAH, IL-1β, Hcy, TNF-α and BDNF in coronary heart disease and its relationship with the severity of coronary stenosis. BMC Cardiovasc Disord 2022;22:101.
38. Bahls M, Könemann S, Markus MRP, Wenzel K, Friedrich N, Nauck M, Völzke H, Steveling A, Janowitz D, Grabe HJ, Felix SB, Dörr M. Brain-derived neurotrophic factor is related with adverse cardiac remodeling and high NTproBNP. Sci Rep 2019;9:15421.
39. Kermani P, Hempstead B. BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to In jury. Front Physiol 2019;10:455.
40. Khalaji A, Behnoush AH, Shobeiri P, Saeedian B, Teixeira AL, Rezaei N. Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta analysis. Sleep Breath 2023;27:829-841.
41. Hang PZ, Zhu H, Li PF, Liu J, Ge FQ, Zhao J, Du ZM. The Emerg ing Role of BDNF/TrkB Signaling in Cardiovascular Diseases. Life (Basel) 2021;11:70.
42. Fulgenzi G, Tomassoni-Ardori F, Babini L, Becker J, Barrick C, Puverel S, Tessarollo L. BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation. J Cell Biol 2015;210:1003-1012.
43. Jiang H, Liu Y, Zhang Y, Chen ZY. Association of plasma brain derived neurotrophic factor and cardiovascular risk factors and prognosis in angina pectoris. Biochem Biophys Res Commun 2011;415:99-103.
44. Zembron-Lacny A, Dziubek W, Rynkiewicz M, Morawin B, Woźniewski M. Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men. Braz J Med Biol Res 2016;49:e5253.
45. Shobeiri P, Karimi A, Momtazmanesh S, Teixeira AL, Teunissen CE, van Wegen EEH, Hirsch MA, Yekaninejad MS, Rezaei N. Exercise-induced increase in blood-based brain-derived neuro trophic factor (BDNF) in people with multiple sclerosis: A sys tematic review and meta-analysis of exercise intervention trial PLoS One 2022;17:e0264557.
46. Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tan don NN, Sun B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000;470:113-117.
47. Ejiri J, Inoue N, Kobayashi S, Shiraki R, Otsui K, Honjo T, Taka hashi M, Ohashi Y, Ichikawa S, Terashima M, Mori T, Awano K, Shinke T, Shite J, Hirata K, Yokozaki H, Kawashima S, Yokoyama M. Possible role of brain-derived neurotrophic factor in the patho genesis of coronary artery disease. Circulation 2005;112:2114- 2120.
48. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neuro trophic factor is an endothelial cell survival factor required for in tramyocardial vessel stabilization. Development 2000;127:4531- 4540.
49. Yoshimura R, Sugita-Ikenouchi A, Hori H, Umene-Nakano W, Hayashi K, Katsuki A, Ueda N, Nakamura J. A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers. Int J Psychiatry Clin Pract 2010;14:220-222.
50. Radka SF, Holst PA, Fritsche M, Altar CA. Presence of brain derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 1996;709:122-301.
51. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kam bayashi J, Sun B, Tandon NN. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002;87:728-734.
52. Pliego-Rivero FB, Bayatti N, Giannakoulopoulos X, Glover V, Bradford HF, Stern G, Sandler M. Brain-derived neurotrophic factor in human platelets. Biochem Pharmacol 1997;54:207-209.
53. Gejl AK, Enevold C, Bugge A, Andersen MS, Nielsen CH, An dersen LB. Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifuga tion strategy. Sci Rep 2019;9:9655.
54. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wil son WD, Xiao G, Blanchi B, Sun YE, Ye K. A selective TrkB ago nist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A 2010;107:2687-2692.
2. Munnur RK, Nerlekar N, Wong DT. Imaging of coronary athero sclerosis in various susceptible groups. Cardiovasc Diagn Ther 2016:382-395.
3. Pasipoularides A. Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology. Int J Cardiol 2017;230:384-401.
4. Wu Y, Pan N, An Y, Xu M, Tan L, Zhang L. Diagnostic and Prog nostic Biomarkers for Myocardial Infarction. Front Cardiovasc Med 2021;7:617277.
5. Raygan F, Etminan A, Mohammadi H, Akbari H, Nikoueinejad H. Serum Levels of Growth Differentiation Factor-15 as an In flammatory Marker in Patients with Unstable Angina Pectoris. J Tehran Heart Cent 2021;16:15-19.
6. Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 2015;11:1164-1178.
7. Scalzo P, Kümmer A, Bretas TL, Cardoso F, Teixeira AL. Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease. J Neurol 2010;257:540-545.
8. Numakawa T, Odaka H, Adachi N. Actions of Brain-Derived Neu rotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases. Int J Mol Sci 2018;19:3650.
9. Clegg DO, Large TH, Bodary SC, Reichardt LF. Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy. Dev Biol 1989;134:30-37.
10. Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tan don NN, Sun B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000;470:113-117.
11. Donovan MJ, Miranda RC, Kraemer R, McCaffrey TA, Tessa rollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L, et al. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 1995;147:309-324.
12. Barouch R, Appel E, Kazimirsky G, Brodie C. Macrophages ex press neurotrophins and neurotrophin receptors. Regulation of ni tric oxide production by NT-3. J Neuroimmunol 2001;112:72-77.
13. Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neu rotrophic factor in vitro and in inflammatory brain lesions: a neu roprotective role of inflammation? J Exp Med 1999;189:865-870.
14. Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM; Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concen trations and the risk of cardiovascular disease in the community. J Am Heart Assoc 2015 Mar;4:e001544.
15. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neuro trophic factor is an endothelial cell survival factor required for in tramyocardial vessel stabilization. Development 2000;127:4531- 4540.
16. László A, Lénárt L, Illésy L, Fekete A, Nemcsik J. The role of neu rotrophins in psychopathology and cardiovascular diseases: psy chosomatic connections. J Neural Transm (Vienna) 2019;126:265- 278.
17. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, Driscoll I, Ferrucci L, Martin B, Mattson MP. Circu lating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One 2010;5:e10099.
18. Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM; Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concen trations and the risk of cardiovascular disease in the community. J Am Heart Assoc. 2015 Mar 11;4(3):e001544.
19. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Pre ferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-269, W64.
20. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta analyses. Eur J Epidemiol 2010;25:603-605.
21. Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quar tile range. Stat Methods Med Res 2018;27:1785-1805.
22. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or in terquartile range. BMC Med Res Methodol 2014;14:135.
23. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Chichester (UK): John Wiley & Sons; 2019. 24. Begg CB, Mazumdar M. Operating characteristics of a rank cor relation test for publication bias. Biometrics 1994;50:1088-1101.
25. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta analysis detected by a simple, graphical test. BMJ 1997;315:629- 634.
26. Amadio P, Cosentino N, Eligini S, Barbieri S, Tedesco CC, San drini L, Zarà M, Fabiocchi F, Niccoli G, Magnani G, Fracassi F, Crea F, Veglia F, Marenzi G, Barbieri SS. Potential Relation be tween Plasma BDNF Levels and Human Coronary Plaque Mor phology. Diagnostics (Basel) 2021;11:1010.
27. Aslan G, Polat V, Bozcali E, Şahin MH, Çetin N, Ural D. Evalua tion of serum platelet-derived growth factor receptor-ß and brain derived neurotrophic factor levels in microvascular angina. Anatol J Cardiol 2020;24:397-404.
28. Bai HL, Lu ZF, Zhao JJ, Ma X, Li XH, Xu H, Wu SG, Kang CM, Lu JB, Xu YJ, Xiao L, Wu Q, Ye S, Wang Q, Zheng L, Hu YW. Microarray profiling analysis and validation of novel long non coding RNAs and mRNAs as potential biomarkers and their func tions in atherosclerosis. Physiol Genomics 2019;51:644-656.
29. Ejiri J, Inoue N, Kobayashi S, Shiraki R, Otsui K, Honjo T, Taka hashi M, Ohashi Y, Ichikawa S, Terashima M, Mori T, Awano K, Shinke T, Shite J, Hirata K, Yokozaki H, Kawashima S, Yokoyama M. Possible role of brain-derived neurotrophic factor in the patho genesis of coronary artery disease. Circulation 2005;112:2114- 2120.
30. Esmaeili F, Mansouri E, Emami MA, Montazerghaem H, Hosseini Teshnizi S, Kheirandish M, Koochakkhani S, Eftekhar E. Asso ciation of Serum Level and DNA Methylation Status of Brain Derived Neurotrophic Factor with the Severity of Coronary Artery Disease. Indian J Clin Biochem 2022;37:159-168.
31. Han W, Zhang C, Wang H, Yang M, Guo Y, Li G, Zhang H, Wang C, Chen D, Geng C, Jiang P. Alterations of irisin, adropin, preptin and BDNF concentrations in coronary heart disease patients co morbid with depression. Ann Transl Med 2019;7:298.
32. Jin H, Chen Y, Wang B, Zhu Y, Chen L, Han X, Ma G, Liu N. As sociation between brain-derived neurotrophic factor and von Will ebrand factor levels in patients with stable coronary artery disease. BMC Cardiovasc Disord 2018;18:23.
33. Monisha KG, Prabu P, Chokkalingam M, Murugesan R, Milen kovic D, Ahmed SSSJ. Clinical utility of brain-derived neuro trophic factor as a biomarker with left ventricular echocardio graphic indices for potential diagnosis of coronary artery disease. Sci Rep 2020;10:16359.
34. Sustar A, Perkovic MN, Erjavec GN, Strac DS, Pivac N. Associa tion between reduced brain-derived neurotrophic factor concentra tion & coronary heart disease. Indian J Med Res 2019;150:43-49.
35. Xia F, Zeng Q, Chen J. Circulating brain-derived neurotrophic factor dysregulation and its linkage with lipid level, stenosis de gree, and inflammatory cytokines in coronary heart disease. J Clin Lab Anal 2022;36:e24546.
36. Florent B, Maxime B, Catherine-Alexandra G, Christine G, Na thalie TT, Eric T, Anil N, Martin J, Jonathan T, Mathieu G, Louis B. Differences in cognitive function, cardiorespiratory fitness and BDNF concentration in physically active CHD patients vs healthy controls. Brain Res 2022;1793:148019.
37. Wu Y, Wang L, Zhan Y, Zhang Z, Chen D, Xiang Y, Xie C. The ex pression of SAH, IL-1β, Hcy, TNF-α and BDNF in coronary heart disease and its relationship with the severity of coronary stenosis. BMC Cardiovasc Disord 2022;22:101.
38. Bahls M, Könemann S, Markus MRP, Wenzel K, Friedrich N, Nauck M, Völzke H, Steveling A, Janowitz D, Grabe HJ, Felix SB, Dörr M. Brain-derived neurotrophic factor is related with adverse cardiac remodeling and high NTproBNP. Sci Rep 2019;9:15421.
39. Kermani P, Hempstead B. BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to In jury. Front Physiol 2019;10:455.
40. Khalaji A, Behnoush AH, Shobeiri P, Saeedian B, Teixeira AL, Rezaei N. Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta analysis. Sleep Breath 2023;27:829-841.
41. Hang PZ, Zhu H, Li PF, Liu J, Ge FQ, Zhao J, Du ZM. The Emerg ing Role of BDNF/TrkB Signaling in Cardiovascular Diseases. Life (Basel) 2021;11:70.
42. Fulgenzi G, Tomassoni-Ardori F, Babini L, Becker J, Barrick C, Puverel S, Tessarollo L. BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation. J Cell Biol 2015;210:1003-1012.
43. Jiang H, Liu Y, Zhang Y, Chen ZY. Association of plasma brain derived neurotrophic factor and cardiovascular risk factors and prognosis in angina pectoris. Biochem Biophys Res Commun 2011;415:99-103.
44. Zembron-Lacny A, Dziubek W, Rynkiewicz M, Morawin B, Woźniewski M. Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men. Braz J Med Biol Res 2016;49:e5253.
45. Shobeiri P, Karimi A, Momtazmanesh S, Teixeira AL, Teunissen CE, van Wegen EEH, Hirsch MA, Yekaninejad MS, Rezaei N. Exercise-induced increase in blood-based brain-derived neuro trophic factor (BDNF) in people with multiple sclerosis: A sys tematic review and meta-analysis of exercise intervention trial PLoS One 2022;17:e0264557.
46. Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tan don NN, Sun B. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000;470:113-117.
47. Ejiri J, Inoue N, Kobayashi S, Shiraki R, Otsui K, Honjo T, Taka hashi M, Ohashi Y, Ichikawa S, Terashima M, Mori T, Awano K, Shinke T, Shite J, Hirata K, Yokozaki H, Kawashima S, Yokoyama M. Possible role of brain-derived neurotrophic factor in the patho genesis of coronary artery disease. Circulation 2005;112:2114- 2120.
48. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neuro trophic factor is an endothelial cell survival factor required for in tramyocardial vessel stabilization. Development 2000;127:4531- 4540.
49. Yoshimura R, Sugita-Ikenouchi A, Hori H, Umene-Nakano W, Hayashi K, Katsuki A, Ueda N, Nakamura J. A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers. Int J Psychiatry Clin Pract 2010;14:220-222.
50. Radka SF, Holst PA, Fritsche M, Altar CA. Presence of brain derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 1996;709:122-301.
51. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kam bayashi J, Sun B, Tandon NN. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002;87:728-734.
52. Pliego-Rivero FB, Bayatti N, Giannakoulopoulos X, Glover V, Bradford HF, Stern G, Sandler M. Brain-derived neurotrophic factor in human platelets. Biochem Pharmacol 1997;54:207-209.
53. Gejl AK, Enevold C, Bugge A, Andersen MS, Nielsen CH, An dersen LB. Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifuga tion strategy. Sci Rep 2019;9:9655.
54. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wil son WD, Xiao G, Blanchi B, Sun YE, Ye K. A selective TrkB ago nist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A 2010;107:2687-2692.
| Files | ||
| Issue | Vol 18 No 4 (2023): J Teh Univ Heart Ctr | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jthc.v18i4.14823 | |
| Keywords | ||
| Brain-derived neurotrophic factor Coronary disease Systematic review Meta-analysis | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Shobeiri P, Behnoush AH, Khalaji A, Teixeira A, Rezaei N. Peripheral Levels of the Brain-Derived Neurotrophic Factor in Coronary Artery Disease: A Systematic Review and Meta-Analysis. J Tehran Heart Cent. 2023;18(4):244-255.
